ISSN 1662-4009 (online)

ey0015.10-1 | Aetiology and heterogeneity of type 1 diabetes | ESPEYB15

10.1 TCF7L2 genetic variants contribute to phenotypic heterogeneity of T1DM

MJ Redondo , S Geyer , AK Steck , J Sosenko , M Anderson , P Antinozzi , A Michels , J Wentworth , P Xu , A Pugliese , T1DM TrialNet Study Group

To read the full abstract: Diabetes Care. 2018;41:311-317Some researchers assume that the etiology of T1DM is distinct from that of Type 2 diabetes mellitus. T1DM is characterized by autoimmune phenomena leading to the destruction of pancreatic islets and most importantly of beta-cells. Genetic factors are thought to influence the likelihood of autoimmune phenomena developing into overt autoimmune di...